Recent Changes

Sunday, February 23

  1. page SLAP interfaces edited SLAP Interfaces This is a list of the ways to run SLAP. Public web app, http://cheminfov.info…

    SLAP Interfaces
    This is a list of the ways to run SLAP.
    Public web app, http://cheminfov.informatics.indiana.edu:8080/slap/. Input Compound ("drug") and Protein, find link if any exists, and association network. Display SLAP network via CytoscapeWeb.
    Public web app, advanced mode, http://cheminfov.informatics.indiana.edu:8080/slap/fileupload.html. Batch mode, for multiple Upload file of drug-target (DT) pairs. Output includes result, Association-Score, and P-Score.
    REST API. Via http://cheminfov.informatics.indiana.edu/rest/Chem2Bio2RDF/slap/.
    REST drug-target pair prediction (DTPP). Format ".../slap/CID:TID"
    Drug-drug similarity based on polypharmacology.
    Similar drugs.
    Python program ppPairPrediction_local.py
    Currently must be run via login on server.
    Input DT pairs.
    Same output as web app advanced mode (includes Association Score).

    (view changes)
    6:12 pm

Sunday, April 1

  1. page API edited ... Rest service for finding similar drugs. http://cheminfov.informatics.indiana.edu/rest/Chem2Bi…
    ...
    Rest service for finding similar drugs.
    http://cheminfov.informatics.indiana.edu/rest/Chem2Bio2RDF/slap/cid=5591
    Change 5591 to any other compounds (e.g, PubChem Compound ID, SMILES, name)
    (view changes)
    10:04 am
  2. page API edited ... http://cheminfov.informatics.indiana.edu/rest/Chem2Bio2RDF/slap/sim_5591:77999 Change 5591 or…
    ...
    http://cheminfov.informatics.indiana.edu/rest/Chem2Bio2RDF/slap/sim_5591:77999
    Change 5591 or 77999 to any other compounds (e.g, PubChem Compound ID, SMILES, name)
    Rest service for finding similar drugs.
    http://cheminfov.informatics.indiana.edu/rest/Chem2Bio2RDF/slap/cid=5591

    (view changes)
    10:03 am
  3. page API edited ... Change 5591 to any other compounds (e.g, PubChem Compound ID, SMILES, name) Change PPARG to a…
    ...
    Change 5591 to any other compounds (e.g, PubChem Compound ID, SMILES, name)
    Change PPARG to any other targets (e.g, Gene Symbol, Uniprot ID, name)
    Rest service for drug drug similarity based on polypharmacology profiles derived from SLAP.
    http://cheminfov.informatics.indiana.edu/rest/Chem2Bio2RDF/slap/sim_5591:77999
    Change 5591 or 77999 to any other compounds (e.g, PubChem Compound ID, SMILES, name)

    (view changes)
    10:02 am

Thursday, December 15

  1. page SAMPLES edited Substructure related: Dexamethasone & annexin A1 5505&KCNJ1 Disease related 65981&…
    Substructure related:
    Dexamethasone & annexin A1
    5505&KCNJ1
    Disease related
    65981&KCNJ1
    4908&HBA1
    Example 1
    Example 2
    Example 3
    Example 4
    Example 5

    (view changes)
    12:31 pm

Saturday, November 26

  1. page home edited ... 4) The similarity between drugs is assessed by their biological fingerprints composed by their…
    ...
    4) The similarity between drugs is assessed by their biological fingerprints composed by their association scores against hundreds of proteins.
    5) Drug indications are extracted from paper (drug target network, nature, 2007)
    ...
    Parkinson disease.
    7) You can download the biological fingerprints of the input drug as well as the similar drugs.

    Target Ligands Prediction:
    Tips:
    (view changes)
    11:57 am

Friday, November 25

  1. page home edited ... 4) The similarity between drugs is assessed by their biological fingerprints composed by their…
    ...
    4) The similarity between drugs is assessed by their biological fingerprints composed by their association scores against hundreds of proteins.
    5) Drug indications are extracted from paper (drug target network, nature, 2007)
    6) example: Ibuprofen, used for Osteoarthritis, has similar drugs Apomorphine, used for Parkinson disease.
    Target Ligands Prediction:
    Tips:
    (view changes)
    6:43 pm

Thursday, November 10

  1. page home edited Semantic Link Association Prediction for Drug Target Prediction GO TO SLAP Web Service About …

    Semantic Link Association Prediction for Drug Target Prediction
    GO TO SLAP Web Service
    About
    ...
    Chem2Bio2OWL). In ourthis system (SLAP),
    Tutorials
    Drug Target Association:
    Tips:
    1) For compound/drug input, you can use name, smiles, or PubChem ID; for target input, you can use gene symbol, protein name, or Uniprot ID. You can also input sequence to retrieve its most similar target.
    ...
    p value <0.01<0.05 is good.
    3) If the association already exists in our database, you can further explore it. The link in the SLAP result section will direct to the original RDF set.
    SAMPLES:
    Network Exploration:
    Tips:
    ...
    3) For 500 pairs, it takes ~2 min.
    Other Predictive Models:
    ...
    the articles ofin which the
    API
    Acknowledgement
    (view changes)
    4:53 pm

More